![]() ![]() His doctor prescribed Seldane to control the allergies and Cipro for an ear infection. Because Bruce suffered from allergies, he was vulnerable to sinusitis. He had to be both focused and calm to get the best shots for his news magazine. We went on to describe the story of Bruce, a professional photographer. Check the average prescription and you will find instructions that are inadequate, ambiguous or incomplete.” Bruce Dodged the Grapefruit Bullet: But they don’t admit that they are partly to blame. They cite statistics that 125,000 people die every year because of medication mistakes. “Physicians and pharmacists often complain that patients don’t take their medicine properly. Here’s what stirred up the hornet’s nest: We wrote a newspaper column nearly 30 years ago that made many doctors mad as hornets. Grapefruit and Drug Interactions Stir People Up: For example, can you take simvastatin or atorvastatin with grapefruit juice? It’s much more complicated than you might think. That is especially true when it comes to statins. Instructions about how to take medicine can be very confusing. Patients may feel like they are also on a conveyer belt when it comes to taking pills. Some pharmacists have confided to us that they feel like they are in an I love Lucy skit like this one where Lucy and Ethel wrap chocolates. nhs.Physicians and pharmacists are super busy these days. Prescription drugs and grapefruit a “deadly mix.” (2012).cc.nih.gov/ccc/patient_education/drug_nutrient/grapefruit1.pdf NIH Clinical Center patient education materials: Important drug and food information.Statins: Are these cholesterol-lowering drugs right for you? /diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045772 diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013 Statin side effects: Weigh the benefits and risks. Effect of low furanocoumarin hybrid grapefruit juice consumption on midazolam pharmacokinetics. heart-health/grapefruit-juice-and-statins fda.gov/forconsumers/consumerupdates/ucm292276.htm Grapefruit juice and some drugs don’t mix.Do your statins and grapefruit safely mix? (2016).(1998) Grapefruit juice-drug interactions. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. It’s also recommended to avoid grapefruit juice when taking other medications, too. Err on the side of caution and restrict drinking and eating grapefruit if you take one of these statins, at least until you discuss the risks with your doctor. No one has the same reaction when mixing grapefruit with lovastatin, atorvastatin, or simvastatin. However, check with your doctor if you experience ill effects, since it’s unclear how common these interactions are. If you accidentally consume a small amount of grapefruit, it isn’t likely to affect your medication. Most incidents of negative reactions involved consuming large amounts of grapefruit. Keep in mind that both fresh and frozen juices have the same effect.Īccording to the Cleveland Clinic, there are instance when consuming moderate amounts of grapefruit appear to be safe. Others may need to consume more of the fruit or juice to have an interaction. Just one grapefruit or one glass of grapefruit juice could be enough to cause an interaction in some people. The exact amount of grapefruit it takes to have a negative reaction when taking lovastatin, atorvastatin, or simvastatin is unknown. How much grapefruit is ok while on certain statins? If you use a skin patch or receive your medication through an injection, you may have a lower risk of adverse effects. This is because the interaction happens in your digestive tract. Interestingly, the interaction between grapefruit and medications poses a danger only when taken orally. Grapefruit doesn’t affect other statins because they are metabolized by a different enzyme, CYP2C9. This compound deactivates the CYP3A4 enzyme that the body uses to metabolize, or process, these particular statins. Furanocoumarins are organic chemical compounds present in many different plants, including grapefruit. The secret to the interaction between grapefruit and these statins is in furanocoumarins, according to a 2017 study. You only need to avoid grapefruit if your doctor prescribes lovastatin, atorvastatin, or simvastatin. For this reason, you might avoid the fruit altogether. One misconception is that you shouldn’t mix grapefruit with any statin drug. If you’re prescribed a statin, it’s important to understand which ones can interact negatively with grapefruit and grapefruit juice. How grapefruit interacts with certain statins
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